2022

Presence and function of Hbl B', the fourth protein component encoded by the hbl operon in Bacillus cereus. Jessberger N, Diedrich R, Janowski R, Niessing D, Märtlbauer E.Virulence. 2022 Dec;13(1):483-501. doi: 10.1080/21505594.2022.2046951.

Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS. Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth TFE, Strauß G, Boldrin E, Posovszky C, Schulz A, Beringer O, Rieser E, Jacobsen EM, Lorenz MR, Schwarz K, Pannicke U, Walczak H, Niessing D, Schuetz C, Fischer-Posovszky P, Debatin KM.EMBO Mol Med. 2022 Mar 7;14(3):e14901. doi: 10.15252/emmm.202114901. Epub 2022 Feb 16.

2021

Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging. Mishra K, Fuenzalida-Werner JP, Pennacchietti F, Janowski R, Chmyrov A, Huang Y, Zakian C, Klemm U, Testa I, Niessing D, Ntziachristos V, Stiel AC. Nat Biotechnol. 2021 Nov 29. doi: 10.1038/s41587-021-01100-5.

The Molecular Function of PURA and Its Implications in Neurological Diseases. Molitor L, Bacher S, Burczyk S, Niessing D. Front Genet. 2021 Mar 11;12:638217. doi: 10.3389/fgene.2021.638217. eCollection 2021.

Transfer of a Rational Crystal Contact Engineering Strategy between Diverse Alcohol Dehydrogenases. Walla, B.; Bischoff, F.; Janowski, R.; von den Eichen, N.; Niessing, D.; Weuster-Botz, D. Crystals 2021, 11, 975. https://doi.org/10.3390/cryst11080975

Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death. Margreiter MA, Witzenberger M, Wasser Y, Davydova E, Janowski R, Metz J, Habib P, Sahnoun SEM, Sobisch C, Poma B, Palomino-Hernandez O, Wagner M, Carell T, Jon Shah N, Schulz JB, Niessing D, Voigt A, Rossetti G. Comput Struct Biotechnol J. 2021 Dec 28;20:443-458. doi: 10.1016/j.csbj.2021.12.029.

UGT76B1, a promiscuous hub of small molecule-based immune signaling, glucosylates N-hydroxypipecolic acid, and balances plant immunity. Bauer S, Mekonnen DW, Hartmann M, Yildiz I, Janowski R, Lange B, Geist B, Zeier J, Schäffner AR. Plant Cell. 2021 May 5;33(3):714-734. doi: 10.1093/plcell/koaa044

2020

Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells. Esgleas M, Falk S, Forné I, Thiry M, Najas S, Zhang S, Mas-Sanchez A, Geerlof A, Niessing D, Wang Z, Imhof A, Götz M.EMBO J. 2020 Aug 17;39(16):e103373. doi: 10.15252/embj.2019103373. Epub 2020 Jul 6.

Challenging a preconception: Optoacoustic spectrum differs from the absorption spectrum of proteins and dyes for molecular imaging. Fuenzalida Werner JP, Huang Y, Mishra K, Janowski R, Vetschera P, Heichler C, Chmyrov A, Neufert C, Niessing D, Ntziachristos V, Stiel AC. Anal Chem. 2020 Jul 8. doi: 10.1021/acs.analchem.0c01902.

Structural basis for the recognition of transiently structured AU-rich elements by Roquin. Binas O, Tants JN, Peter SA, Janowski R, Davydova E, Braun J, Niessing D, Schwalbe H, Weigand JE, Schlundt A.Nucleic Acids Res. 2020 Jun 3:gkaa465. doi: 10.1093/nar/gkaa465.

The large family of PC4-like domains - similar folds and functions throughout all kingdoms of life. Janowski R, Niessing D.RNA Biol. 2020 May 31:1-11. doi: 10.1080/15476286.2020.1761639.

Crystal Contact Engineering Enables Efficient Capture and Purification of an Oxidoreductase by Technical Crystallization. Grob P, Huber M, Walla B, Hermann J, Janowski R, Niessing D, Hekmat D, Weuster-Botz D.Biotechnol J. 2020 Apr 17:e2000010. doi: 10.1002/biot.202000010.

Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics. Su W, Tan H, Janowski R, Zhang W, Wang P, Zhang J, Zhai H, Li J, Niessing D, Sattler M, Zou P.Mol Pharm. 2020 May 4;17(5):1663-1673. doi: 10.1021/acs.molpharmaceut.0c00098.

2019

Defining and expanding the phenotype of QARS-associated developmental epileptic encephalopathy. Johannesen KM, Mitter D, Janowski R, Roth C, Toulouse J, Poulat AL, Ville DM, Chatron N, Brilstra E, Geleijns K, Born AP, McLean S, Nugent K, Baynam G, Poulton C, Dreyer L, Gration D, Schulz S, Dieckmann A, Helbig KL, Merkenschlager A, Jamra R, Finck A, Gardella E, Hjalgrim H, Mirzaa G, Brancati F, Bierhals T, Denecke J, Hempel M, Lemke JR, Rubboli G, Muschke P, Guerrini R, Vetro A, Niessing D, Lesca G, Møller RS.Neurol Genet. 2019 Dec 10;5(6):e373. doi: 10.1212/NXG.0000000000000373.

Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains. Heber S, Gáspár I, Tants JN, Günther J, Moya SMF, Janowski R, Ephrussi A, Sattler M, Niessing D. Nat Commun. 2019 Apr 10;10(1):1659. doi: 10.1038/s41467-019-09655-3.

2018

Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation. Fuenzalida-Werner JP, Janowski R, Mishra K, Weidenfeld I, Niessing D, Ntziachristos V, Stiel AC. J Struct Biol. 2018 Oct 1. pii: S1047-8477(18)30273-9. doi: 10.1016/j.jsb.2018.09.013.

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs. Węglarz-Tomczak E, Talma M, Giurg M, Westerhoff HV, Janowski R, Mucha A. Oncotarget. 2018 Jun 29;9(50):29365-29378. doi: 10.18632/oncotarget.25532. eCollection 2018 Jun 29.

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor. Tretter JY, Schorpp K, Luxenburger E, Trambauer J, Steiner H, Hadian K, Gires O, Niessing D. J Biol Chem. 2018 Jun 8;293(23):8994-9005. doi: 10.1074/jbc.RA118.002776. Epub 2018 Apr 26.

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation. Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D. Cell. 2018 Apr 19;173(3):706-719.e13. doi: 10.1016/j.cell.2018.03.004.

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V. Nat Commun. 2018 Jan 19;9(1):299. doi: 10.1038/s41467-017-02582-1.

mRNA transport in fungal top models. Niessing D, Jansen RP, Pohlmann T, Feldbrügge M. Wiley Interdiscip Rev RNA. 2018 Jan;9(1). doi: 10.1002/wrna.1453. Epub 2017 Oct 10. Review.

PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature. Reijnders MRF, Janowski R, Alvi M, Self JE, van Essen TJ, Vreeburg M, Rouhl RPW, Stevens SJC, Stegmann APA, Schieving J, Pfundt R, van Dijk K, Smeets E, Stumpel CTRM, Bok LA, Cobben JM, Engelen M, Mansour S, Whiteford M, Chandler KE, Douzgou S, Cooper NS, Tan EC, Foo R, Lai AHM, Rankin J, Green A, Lönnqvist T, Isohanni P, Williams S, Ruhoy I, Carvalho KS, Dowling JJ, Lev DL, Sterbova K, Lassuthova P, Neupauerová J, Waugh JL, Keros S, Clayton-Smith J, Smithson SF, Brunner HG, van Hoeckel C, Anderson M, Clowes VE, Siu VM, Ddd Study T, Selber P, Leventer RJ, Nellaker C, Niessing D, Hunt D, Baralle D. J Med Genet. 2018 Feb;55(2):104-113. doi: 10.1136/jmedgenet-2017-104946. Epub 2017 Nov 2.

2017

Evidence for Complex Formation of the Bacillus cereus Haemolysin BL Components in Solution. Tausch F, Dietrich R, Schauer K, Janowski R, Niessing D, Märtlbauer E, Jessberger N. Toxins (Basel). 2017 Sep 16;9(9). pii: E288. doi: 10.3390/toxins9090288.

Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator. Schlundt A, Buchner S, Janowski R, Heydenreich T, Heermann R, Lassak J, Geerlof A, Stehle R, Niessing D, Jung K, Sattler M. Sci Rep. 2017 Apr 21;7(1):1051. doi: 10.1038/s41598-017-01031-9.

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex. Edelmann FT, Schlundt A, Heym RG, Jenner A, Niedner-Boblenz A, Syed MI, Paillart JC, Stehle R, Janowski R, Sattler M, Jansen RP, Niessing D. Nat Struct Mol Biol. 2017 Feb;24(2):152-161. doi: 10.1038/nsmb.3351.

2016

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4. Janowski R, Scanu S, Niessing D, Madl T. Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):743-749.

Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40. Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M. Nat Commun. 2016 Mar 24;7:11032. doi: 10.1038/ncomms11032

RNA recognition by Roquin in posttranscriptional gene regulation. Schlundt A, Niessing D, Heissmeyer V, Sattler M. Wiley Interdiscip Rev RNA. 2016 Jul;7(4):455-69. doi: 10.1002/wrna.1333. Review.

Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. Weber J, Bao H, Hartlmüller C, Wang Z, Windhager A, Janowski R, Madl T, Jin P, Niessing D. Elife. 2016 Jan 8;5. pii: e11297. doi: 10.7554/eLife.11297.

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D. Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934.

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity. Morgen M, Jöst C, Malz M, Janowski R, Niessing D, Klein CD, Gunkel N, Miller AK. ACS Chem Biol. 2016 Apr 15;11(4):1001-11. doi: 10.1021/acschembio.5b00755.

2015

ASH1 mRNP-core factors form stable complexes in absence of cargo RNA at physiological conditions. Edelmann FT, Niedner A, Niessing D. RNA Biol. 2015;12(3):233-7. doi: 10.1080/15476286.2015.1017217.

2014

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation. Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, Sattler M. Nat Struct Mol Biol. 2014 Aug;21(8):671-8. doi: 10.1038/nsmb.2855.

Of social molecules: The interactive assembly of ASH1 mRNA-transport complexes in yeast. Niedner A, Edelmann FT, Niessing D. RNA Biol. 2014;11(8):998-1009. doi: 10.4161/rna.29946. Review.

mRNA transport meets membrane traffic. Jansen RP, Niessing D, Baumann S, Feldbrügge M. Trends Genet. 2014 Sep;30(9):408-17. doi: 10.1016/j.tig.2014.07.002. Review.

Production of pure and functional RNA for in vitro reconstitution experiments. Edelmann FT, Niedner A, Niessing D. Methods. 2014 Feb;65(3):333-41. doi: 10.1016/j.ymeth.2013.08.034. Review.

2013

In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation. Heym RG, Zimmermann D, Edelmann FT, Israel L, Ökten Z, Kovar DR, Niessing D. J Cell Biol. 2013 Dec 23;203(6):971-84. doi: 10.1083/jcb.201302095.

Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c. Velvarska H, Niessing D. PLoS One. 2013 Dec 10;8(12):e82065. doi: 10.1371/journal.pone.0082065.

Role of Loc1p in assembly and reorganization of nuclear ASH1 messenger ribonucleoprotein particles in yeast. Niedner A, Müller M, Moorthy BT, Jansen RP, Niessing D. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5049-58. doi: 10.1073/pnas.1315289111.

Purification, crystallization and preliminary crystallographic analysis of the globular domain of the human type V myosin Myo5a. Velvarska H, Niessing D. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1220-3. doi: 10.1107/S1744309113025578.

Structural features of Argonaute-GW182 protein interactions. Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3770-9. doi: 10.1073/pnas.1308510110.

2012
Purification, crystallization and preliminary crystallographic analysis of Kar9p from Saccharomyces cerevisiae. Hüls D, Niessing D. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1251-4. doi: 10.1107/S1744309112036342.

Assembly of mRNA-protein complexes for directional mRNA transport in eukaryotes--an overview. Jansen RP, Niessing D. Curr Protein Pept Sci. 2012 Jun;13(4):284-93. Review.

Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte. Aumiller V, Graebsch A, Kremmer E, Niessing D, Förstemann K. RNA Biol. 2012 May;9(5):633-43. doi: 10.4161/rna.19760.